Home Genetics Linkage and Crossing over

Linkage and Crossing over

by Ramneet Kaur
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 Linkage

A chromosome possesses many genes & all genes present in the chromosome are inherited together.

Linkage: Study of inheritance of all genes present in a chromosome together.

  • All genes in a chromosome are together referred as linked genes & they form a linkage group.
  • The total number of linkage group in an organism is equal to its haploid number of chromosomes.
Bateson & Punnet:
  • While working on sweet pea (Lathyrus odoratus) observed that genes for flower color & pollen shape remain together and do not assort independently according to Mendel’s law of Independent assortment.
  • Test cross failed to produce 1:1:1:1 ratio & instead produced 7:1:1:7.
  • They gave the Coupling & Repulsion theory:
  • Coupling: when genes come from the same parent they enter the same gamete & are inherited together.
  • Repulsion: genes are inherited separately when genes come from different parents  & they enter different gametes

T H Morgan’s Linkage:

He worked on Drosophila.

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  • linked genes are genes present on the same chromosome.
  • Linked genes are inherited together.
  • Genes are linearly arranged in a chromosome.
  • Strength of linkage: Genes which are closely located show strong linkage & genes which are located far show weak linkage.
  • He stated that Coupling & Repulsion are two aspects of Linkage.
  • Linked genes show 2 types of arrangement:
  1. Cis arrangement: dominant alleles of 2 or more genes are present in one chromosome & its recessive alleles in its homologue. AB/ab. This is Coupling.
  2. Trans arrangement: the dominant allele of one pair & recessive of the other pair together lie in a chromosome.Ab/aB. This is Repulsion.
  • Linked genes are of 2 types:
  1. Complete linkage: genes for 2 or more characters appear together for two or more generations in their parental combination.They are closely located in the chromosome.
  2. Incomplete linkage: the parental combination of 2 or more characters are not retained in the next generations.They are not closely located in the chromosome.
  • Incomplete linkage occurs due to crossing over.

Morgan’s experiment:

Crossing over:

  • It is the exchange of segments between non-sister chromatids of homologous chromosomes.
  • It occurs during pachytene stage of prophase I in meiosis.
  • Crossing over always occurs between linked genes.
  • It produces recombination of linked genes which play very important role in evolution.
  • Recombination frequency helps in finding out the distance between genes. Given by Sturtevant.
  • Recombination frequency helps in the construction of genetic maps of the chromosomes.

In a dihybrid cross:

  • When the test cross result is 1:1, genes are linked and there is no crossing over.
  • If the test cross result is 1:1:1:1 means the genes are independently assorting (present on separate chromosomes).
  • If in the test cross result parental combination is more than 50% & recombination is less than 50%, the genes are linked and crossing over has occurred.

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4 comments

12361236d October 22, 2018 - 9:29 pm

Nice notes
Helpful in self studies

Reply
Ramneet Kaur October 22, 2018 - 10:32 pm

Thanks

Reply
sonia garg February 28, 2019 - 9:18 pm

its very relevant and exact informations thats what i want to know than other articles…
please mam help me to make the punnet square to obtain 7:1:1:7 ration…

Reply
Ramneet Kaur March 7, 2019 - 12:04 pm

Thanks…. you don’t need it

Reply

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